PICASO COSMETIC LABORATORY GROUP.

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    • PICASO COSMETIC LABORATORY LIMITED
    • COSME NATURALS,LIMITED
    • BEAUTY COSMETICS,LIMITED
    • PICASO NATURALS,LIMITED
    • PICASO NATURALS LABORATORY CO., LTD.
    • BISO LABORATORY (SHANGHAI) LIMITED
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    • PICASO COSMETIC LABORATORY LIMITED
    • COSME NATURALS,LIMITED
    • BEAUTY COSMETICS,LIMITED
    • PICASO NATURALS,LIMITED
    • PICASO NATURALS LABORATORY CO., LTD.
    • BISO LABORATORY (SHANGHAI) LIMITED
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積み重ねてきた「美」の伝統

Research and Development

Leveraging the latest advances in skin and cosmetic science, we develop safe, effective formulations and functional ingredients.

With laboratories and offices in Osaka, Tokyo, Shanghai, and Bangkok supported by 120 technical experts worldwide, we rapidly engineer market-specific formulations that resonate regionally while maintaining global quality standards. Leveraging patented ingredients and proprietary R&D methodologies, we deliver scientifically validated products combining clinical efficacy with commercial viability across all markets.

Formulation Development
Capability

Drawing on decades of specialized expertise and proprietary technologies, we engineer unique formulations with proven market differentiation. Our portfolio of 200,000+ developed formulas spans skincare, cosmetics, haircare, and body care categories, supported by patented innovations that address evolving consumer demands through scientifically validated solutions.

Functional Ingredient
Development

At PICASO, we are also dedicated to developing our own original ingredients. Our attractive product proposals feature unique materials such as collagen ferment filtrate made with premium domestic marine collagen, fast-acting galactomyces ferment filtrate, patented Uminoglycan (mucopolysaccharide), and Miang extract, which we presented at the IFSCC Congress 2020.

Approval for Quasi-drugs
(Japan’s Category of Medicinal Cosmetics)

In addition to developing formulations based on customer requests, we are constantly at the forefront of formulation innovation, holding over 100 in-house quasi-drug formulas. While obtaining approval for a quasi-drug typically takes six months to a year from application to approval, our existing in-house formulations enable faster, more efficient commercialization.

Safety Evaluation

We conduct safety evaluation tests to ensure that the products we propose can be used safely and securely by our customers.
For in vivo testing, we primarily perform actual-use tests, along with patch tests, stinging tests, and RIPTs (Repeated Insult Patch Tests) as needed.
For in vitro testing, we carry out animal-free skin irritation and phototoxicity tests, as well as cell-based eye irritation tests.

Efficacy Evaluation

We conduct a wide range of efficacy evaluation tests, from cellular-level studies to human trials, to provide ingredients and products backed by scientific evidence.
Our evaluations include brightening effect tests, dark spot and pore assessments, skin texture and moisture retention measurements, and SPF assessments using a UV transmittance analyzer — enabling us to deliver high value-added products.

Global Support

We have production and R&D bases in Shanghai, China, and Bangkok, Thailand. Working closely with our local teams, we develop global formulations that comply with China’s NMPA regulations, halal requirements, and the ASEAN Cosmetic Directive.
Through close coordination between specialized sections at each site, we swiftly identify the diverse needs of each market and respond with flexibility.

HOME > About Our Business > Research and Development
About Our Business
Concept & Proposal
Development Flow
Research & Development
Our Manufacturing Portfolio
Production Equipment
Quality Control
Company Information
PICASO COSMETIC LABORATORY LIMITED
COSME NATURALS,LIMITED
BEAUTY COSMETICS,LIMITED
PICASO NATURALS,LIMITED
PICASO NATURALS LABORATORY CO., LTD.
BISO LABORATORY (SHANGHAI) LIMITED
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Head Office & Central Laboratory
Tokyo Office & Laboratory
Kobe Factory
Yokohama Factory
No.2 Yokohama Factory
Yokohama Technical Center
No.1 Bangkok Factory & Laboratory
No.2 Bangkok Factory
Shanghai Factory & Laboratory
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